The publications listed below acknowledge Grand Challenge funding.

• Pearson JA, Hanna SJ (2025) Mini review: Interleukin-32 as a key mediator of type 1 diabetes pathogenesis. Frontiers in Immunology. doi: 10.3389/fimmu.2025.1641698

• Hansford R, Buller S, Tsang AH, Benoit S, Roberts AG, Erskine E, Brown T, Pirro V, Reimann F, Harada N, Inagaki N, Samms RJ, Broichhagen J, Hodson DJ, Adriaenssens A, Park S, Blouet C (2025) Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism. Cell Metabolism. doi: 10.1016/j.cmet.2025.07.009

• Wong CK, Yusta B, Tong JCL, Broichhagen J, Hodson DJ, Drucker DJ (2025) Reassessment of antibody-based detection of the murine T cell GLP-1 receptor. Cell Metabolism. doi: 10.1016/j.cmet.2025.06.012

• Alhamar G, Fallucca S, Richardson SJ, Torabi F, Christie MR, Vadakekolathu J, Boocock DJ, Pieralice S, Manfrini S, Pozzilli P (2025) Raised levels of Interleukin-8 and myeloperoxidase in patients with recent onset type 1 diabetes. Diabetes Obesity and Metabolism. doi: 10.1111/dom.70048

• de Bray A, Roberts AG, Armour S, Tong J, Huhn C, Gatin-Fraudet B, Roßmann K, Shilleh AH, Jiang W, Figueredo Burgos NS, Trott JPP, Viloria K, Nasteska D, Pearce A, Miyazaki S, Tomlinson JW, Owen DM, Nieves DJ, Ast J, Cyranka M, Epanchintsev A, Ämmälä C, Reimann F, Soykan T, Ladds G, Adriaenssens AE, Trapp S, Jones B, Broichhagen J, Hodson DJ (2025) Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain. Nature Metabolism. doi: 10.1038/s42255-025-01342-6

• Varas N, Jarosinski MA, Chen Y-S, Ni C-L, Grabowski RA, Tai N, Herzog RI, Ismail-Beigi F, Yang Y, Cherrington AD, Weiss MA (2025) Ultrastable Insulin-Glucagon Fusion Protein Exploits an Endogenous Hepatic Switch to Mitigate Hypoglycemic Risk. ACS Pharmacology & Translational Science. doi: 10.1021/acsptsci.5c00362

• Evans-Molina C, Dor Y, Lernmark A, Mathieu C, Millman JR, Mirmira RG, Pociot F, Redondo MJ, Rich SS, Richardon SJ, Rickels MR, Leslie RD (2025) The heterogeneity of type 1 diabetes: implications for pathogenesis, prevention, and treatment—2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum. Diabetologia. doi: 10.1007/s00125-025-06462-y

• Tong JCL, Frazer-Morris C, Shilleh AH, Viloria K, de Bray A, Nair AM, Johnson PRV, Spiers R, Kobiita A, Olaniru OE, Persaud SJ, Hauffe R, Kleinridders A, Schultz C, Verchere CB, Cui C, Campbell JE, Cyranka M, Epanchintsev A, Ämmälä C, Broichhagen J, Hodson DJ (2025) Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication. Cell Metabolism. doi: 10.1016/j.cmet.2025.06.009

• Capozzi ME, Bouslov D, Sargsyan A, Chan MY, Gray SM, Viloria K, Bareja A, Douros JD, Lewandowski SL, Tong JCL, Hasib A, Cuozzo F, Ross EC, Foster MW, Weinstein LS, Hussain MA, Merrins MJ, Willard FS, Huising MO, Sloop KW, Hodson DJ, D’Alessio DA, Campbell JE (2025) β-cell Gɑs signaling is critical for physiological and pharmacological enhancement of insulin secretion. The Journal of Clinical Investigation. doi: 10.1172/jci183741

• Forbes S (2025) β-Cell Benchmarks: Defining Predictive Outcomes in Islet Transplantation. Diabetes. doi: 10.2337/dbi24-0054

• Kryukova J, Vales S, Payne M, Smagurauskaite G, Chandra S, Clark CJ, Davies G, Bhattacharya S (2025) Development of chemokine network inhibitors using combinatorial saturation mutagenesis. Communications Biology. doi: doi.org/10.1038/s42003-025-07778-6

• Hibbert JE, Huang J, Akerman I (2025) The UK’s role in the future of therapy for type 1 diabetes. The Endocrinologist.

• Rodriguez-Calvo T, Laiho JE, Oikarinen M, Akhbari P, Flaxman C, Worthington T, Apaolaza P, Kaddis JS, Kusmartseva I, Tauriainen S, Campbell-Thompson M, Atkinson MA, von Herrath M, Hyöty H, Morgan NG, Pugliese A, Richardson SJ (2025) Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes. Diabetologia. doi: 10.1007/s00125-025-06384-9

• Richardson SJ, Rodriguez-Calvo T, Laiho JE, Kaddis JS, Nyalwidhe JO, Kusmartseva I, Morfopoulou S, Petrosino JF, Plagnol V, Maedler K, Morris MA, Nadler JL, Atkinson MA, von Herrath M, Lloyd RE, Hyöty H, Morgan NG, Pugliese A (2025) Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue. Diabetologia. doi: 10.1007/s00125-025-06401-x

• Dewhurst-Trigg RE, Atkins J, Morgan NG, Eichmann M, Richardson SJ, Rackham CL (2025) Characterisation of native human pancreatic mesenchymal stromal cells in type 1 diabetes. bioRxiv. doi: 10.1101/2025.03.05.641596

• Akhbari P, Perez-Hernandez J, Russell MA, Dhayal S, Leslie KA, Hunter SL, Murrall K, Carré A, Morgan NG, Mallone R, Richardson SJ (2025) Soluble HLA class I is released from human β-cells following exposure to interferons. Diabetes. doi: 10.2337/db24-0827

• Bastl C, Close CM, Holtz I, Gatin-Fraudet B, Eis M, Werum M, Konrad S, Kneller L, Roßmann K, Huhn C, Ghosh S, Ast J, Roosen DA, Lehmann M, Haucke V, Reymond L, Hodson DJ, Tinnefeld P, Johnsson K, Glembockyte V, Kilian N, Broichhagen J (2025). A Silicon Rhodamine-fused Glibenclamide to Label and Detect Malaria-infected Red Blood Cells. ChemBioChem. doi: 10.1002/cbic.202400628

• Carré A, Samassa F, Zhou Z, Perez-Hernandez J, Lekka C, Manganaro A, Oshima M, Liao H, Parker R, Nicastri A, Brandao B, Colli ML, Eizirik DL, Aluri J, Patel D, Göransson M, Burgos Morales O, Anderson A, Landry L, Kobaisi F, Scharfmann R, Marselli L, Marchetti P, You S, Nakayama M, Hadrup SR, Kent SC, Richardson SJ, Ternette N, Mallone R (2025) Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells. Nature Communications. doi: 10.1038/s41467-025-55908-9

• Lee CZW, Spagnoli FM (2024) Nurturing protectors: Macrophages in the human pancreatic islet. Cell Stem Cell. doi: 10.1016/j.stem.2024.10.006

• Hanna SJ, Bonami RH, Corrie B, Westley M, Posgai AL, Luning Prak ET, Breden F, Michels AW, Brusko TM, Type 1 Diabetes AIRR Consortium (2024) The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium. Diabetologia. doi: 10.1007/s00125-024-06298-y

• Collins J, Barra JM, Holcomb K, Ocampo A, Fremin A, Akolade J, Kratz A, Hays JK, Shilleh A, Hodson DJ, Broichhagen J, Russ HA, Farnsworth NL (2024) Peptide Coated Polycaprolactone-Benzalkonium Chloride Nanocapsules for Targeted Drug Delivery to the Pancreatic β-Cell. bioRxiv. doi: 10.1101/2024.07.15.603612

• Forbes S, Kay TWH (2024). Islet transplantation in kidney transplant recipients with type 1 diabetes. The Lancet Diabetes & Endocrinology. doi: 10.1016/S2213-8587(24)00274-2

• Hussain S, Braune K, Forbes S, Senior PA (2024) Closed-loop systems: a bridge to cell therapy for type 1 diabetes? The Lancet Diabetes & Endocrinology. doi: 10.1016/S2213-8587(24)00240-7

• Dewhurst-Trigg R, Hopkinson J, Richardson SJ, Jones P, Rackham C (2024) Mesenchymal stromal cells and their secretory products reduce the inflammatory crosstalk between islets and endothelial cells. Endocrine. doi: 10.1007/s12020-024-03975-1

• Pauza AG, Thakkar P, Shen X, Felippe I, Roßmann K, Oya M, Nakamura K, Broichhagen J, Hodson DJ, Pauza DHm Murphy D, Paton JFR (2024) Melanocortin system activates carotid body arterial chemoreceptors in hypertension. bioRxiv. doi: 10.1101/2024.07.22.604704

• Thorens B, Hodson DJ (2024) Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 Diabetes Classic by Thorens et al. Diabetes. doi: 10.2337/dbi24-0025

• Robertson E, Sutcliffe J, Connor R, Heller SR (2024) The type 1 diabetes grand challenge: The potential for transformative impact from the largest ever investment, £50 million and collaborative thinking across the UK. Diabetic Medicine. doi: 10.1111/dme.15376

• Cuozzo F, Viloria K, Shilleh AH, Nasteska D, Frazer-Morris C, Tong J, Jiao Z, Boufersaoui A, Marzullo B, Rosoff DB, Smith HR, Bonner C, Kerr-Conte J, Pattou F, Nano R, Piemonti L, Johnson PRV, Spiers R, Roberts J, Lavery GG, Clark A, Ceresa CDL, Ray DW, Hodson L, Davies AP, Rutter GA, Oshima M, Scharfmann R, Merrins MJ, Akerman I, Tennant DA, Ludwig, Hodson DJ (2024) LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells. Cell Reports. doi: 10.1016/j.celrep.2024.114047

• Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S, nPOD-Virus Working Group, You S, Pugliese A, Hyöty H, Rodriguez-Calvo T, Flodström-Tullberg M, Mallone R (2024) Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses. Science Advances. doi: 10.1126/sciadv.adl1122

• Shilleh AH, Viloria K, Broichhagen J, Campbell JE, Hodson DJ (2024) GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells. Peptides. doi: 10.1016/j.peptides.2024.171179

• Russell MA, Richardson SJ, Morgan NG (2023) The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes. Front Endocrinol. doi: 10.3389/fendo.2023.1270325

• Cantley J, Eizirik, DL, Latres E, Dayan CM, the JDRF-DiabetesUK-INNODIA-nPOD Stockholm Symposium 2022 (2023) Islet cells in human type 1 diabetes: from recent advances to novel therapies – a symposium-based roadmap for future research. Journal of Endocrinology. doi: 10.1530/JOE-23-0082